{"id":4163,"date":"2024-08-07T16:01:13","date_gmt":"2024-08-07T08:01:13","guid":{"rendered":"https:\/\/www.epshk.hk\/?p=4163"},"modified":"2024-08-07T16:01:13","modified_gmt":"2024-08-07T08:01:13","slug":"the-results-of-a-study-on-the-usefulness-of-sublingual-vaccines-in-influenza-made-the-cover-of-the-scientific-journal-vaccines","status":"publish","type":"post","link":"https:\/\/www.epshk.hk\/en\/the-results-of-a-study-on-the-usefulness-of-sublingual-vaccines-in-influenza-made-the-cover-of-the-scientific-journal-vaccines\/","title":{"rendered":"The results of a study on the usefulness of sublingual vaccines in influenza made the cover of the scientific journal Vaccines"},"content":{"rendered":"

\u3000Our paper on the efficacy and safety of sublingual vaccine in influenza was published in the scientific journal Vaccines.
\n\u3000Furthermore, this paper was selected for the cover of \u201dVaccines, Volume 12, Issue 6 (June 2024)\u201d, which features 139 articles, and has garnered significant attention from researchers.
\n\u3000Cover URL: https:\/\/www.mdpi.com\/2076-393X\/12\/6<\/a><\/p>\n

Title of the Thesis\uff1a
\n\u3000Molecular Events in Immune Responses to Sublingual Influenza Vaccine with Hemagglutinin Antigen and Poly(I:C) Adjuvant in Nonhuman Primates, Cynomolgus Macaques
\n\u3000Journal title\uff1aVaccines
\n\u3000Author Name\uff1a Tetsuro Yamamoto, Makoto Hirano, Fusako Mitsunaga, Kunihiko Wasaki, Atsushi Kotani,\u3000Kazuki Tajima, Shin Nakamura
\n\u3000DOI\uff1ahttps:\/\/doi.org\/10.3390\/vaccines12060643
\n\u3000URL\uff1ahttps:\/\/www.mdpi.com\/2076-393X\/12\/6\/643<\/a><\/p>\n

Thesis Outline\uff1a
\n\u3000Sublingual administration of influenza virus HA antigen and the adjuvant Poly(I:C) to cynomolgus monkeys induced both mucosal and systemic immune responses. For mucosal immunity, HA antigen-specific secretory IgA was produced in saliva and nasal lavage fluid. For systemic immunity, HA antigen-specific IgA and IgG were produced in the blood. The safety of this vaccine was confirmed through blood tests. Additionally, the vaccine was shown not to increase inflammatory cytokines or upregulate gene expression of pro-inflammatory cytokines.<\/p>\n

\u3000Previously, we have reported on the utility of sublingual vaccines against SARS-CoV-2*, but the results of this study demonstrate efficacy against a different antigens, indicating the potential applicability of sublingual vaccines against a wide range of infectious diseases.<\/p>\n

\u3000Sublingual vaccines hold promise for \u201dease of self-administration by patients\u201d, \u201dbroad efficacy ranging from infection prevention to reduction of severe cases\u201d and \u201dhigh safety profile\u201d. Through our research and development of sublingual vaccines, our company aims to realize a healthy society capable of responding to pandemic infectious diseases.<\/p>\n

*Name of the Thesis\uff1a
\n\u3000SARS-CoV-2 sublingual vaccine with RBD antigen and poly(I:C) adjuvant: Preclinical study in cynomolgus macaques
\n\u3000DOI\uff1a10.1093\/biomethods\/bpad017
\n\u3000URL\uff1ahttps:\/\/academic.oup.com\/biomethods\/article\/8\/1\/bpad017\/7266774<\/a><\/p>\n

\u3010About EPS Innovative Medicine (Japan) Co., Ltd.\u3011
\n\u3000EPS Innovative Medicine (Japan) Co., Ltd. is the core company of the drug discovery and development of the healthcare business operated by EPS Creative Health Technology Group Limited. Our business is to enhance the value of drug candidates and technologies introduced by our joint venture (JV), which is a company of our group, or those found in our research division, by combining the knowledge and know-how accumulated by EPS Group over many years and promoting clinical development on our own. We will then realize the manufacturing and launching in Japan and particularly in China or licensing them to our partner enterprises. <\/p>\n","protected":false},"excerpt":{"rendered":"

\u3000Our paper on the efficacy and safety of sublingual vaccine in influenza was published in the scientific journal Vaccines. \u3000Furthermore, this paper was selected for the cover of \u201dVaccines, Volume 12, Issue 6 (June 2024)\u201d, which features 139 articles, and has garnered significant attention from researchers. \u3000Cover URL: https:\/\/www.mdpi.com\/2076-393X\/12\/6 Title of the Thesis\uff1a \u3000Molecular Events […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[70],"tags":[],"yoast_head":"\nThe results of a study on the usefulness of sublingual vaccines in influenza made the cover of the scientific journal Vaccines - EPS Creative Health<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mal.epshk.hk\/en\/the-results-of-a-study-on-the-usefulness-of-sublingual-vaccines-in-influenza-made-the-cover-of-the-scientific-journal-vaccines\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The results of a study on the usefulness of sublingual vaccines in influenza made the cover of the scientific journal Vaccines - 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